Efficient confidence limits for adaptive one-arm two-stage clinical trials with binary endpoints
نویسندگان
چکیده
منابع مشابه
Efficient confidence limits for adaptive one-arm two-stage clinical trials with binary endpoints
BACKGROUND Recently, several adaptive one-arm two-stage designs have been developed by fully using the information from previous stages to reduce the expected sample size in clinical trials with binary endpoints as primary outcome. It is important to compute exact confidence limits for these studies. METHODS In this article, we propose three new one-sided limits by ordering the sample space b...
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ژورنال
عنوان ژورنال: BMC Medical Research Methodology
سال: 2017
ISSN: 1471-2288
DOI: 10.1186/s12874-017-0297-5